SPT16

FACT complex subunit (SPT16/CDC68)
SPT16
SMART accession number:SM01286
Description: Proteins in this family are subunits the FACT complex. The FACT complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin PMID:15987999.
Interpro abstract (IPR013953):

Proteins in this entry are subunits the FACT complex; the FACT complex is a stable heterodimer in Saccharomyces cerevisiae (Baker's yeast) comprising Spt16p and Pob3p. The complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin [(PUBMED:15987999)]; it also facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilising and then reassembling nucleosome structure [(PUBMED:12524332), (PUBMED:12934006)].

The proteins in this entry are non-peptidase homologues belonging to MEROPS peptidase family M24 (clan MG).

Family alignment:
View or

There are 1690 SPT16 domains in 1688 proteins in SMART's nrdb database.

Click on the following links for more information.