SWIBSWI complex, BAF60b domains
|SMART accession number:||SM00151|
|Interpro abstract (IPR019835):|
The SWI/SNF family of complexes, which are conserved from yeast to humans, are ATP-dependent chromatin-remodelling proteins that facilitate transcription activation [(PUBMED:11147808)]. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). The BAF60 family have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. BAF60b is present in alternative forms of the SWI/SNF complex, including complex B (SWIB), which lacks BAF60a. The SWIB domain is a conserved region found within the BAF60b proteins [(PUBMED:12016060)], and can be found fused to the C terminus of DNA topoisomerase in Chlamydia.
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