Skp1Found in Skp1 protein family
|SMART accession number:||SM00512|
|Description:||Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.|
|Interpro abstract (IPR001232):|
This entry includes SKP1 and SKP1-like proteins.
S-phase kinase-associated protein 1 (SKP1) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex [(PUBMED:10205047)]. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [(PUBMED:8670864)] and is also involved in the ubiquitin pathway [(PUBMED:9390558)]. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [(PUBMED:7852383)].
SKP1-like proteins in this entry include transcription elongation factor B polypeptide 1 (TCEB1, also known as RNA polymerase II transcription factor SIII subunit C) from animals and elongin-C from yeasts. TCEB1 is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites [(PUBMED:15590694)]. It forms a complex with SIII regulatory subunits B, which serves as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes [(PUBMED:15590694)]. Elongin-C forms a complex with Cul3 that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis [(PUBMED:17296727)].
|GO process:||ubiquitin-dependent protein catabolic process (GO:0006511)|
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)