THAP |
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| SMART accession number: | SM00980
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| Description: |
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes (PUBMED:12575992). |
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| Family alignment: |
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There are 1126
THAP domains in 816 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Cellular role (predicted cellular role)
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Cellular role: chromatin
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Roussigne M et al.
- The THAP domain: a novel protein motif with similarity to the DNA-bindingdomain of P element transposase.
- Trends Biochem Sci. 2003; 28: 66-9
- Display abstract
We have identified a novel evolutionarily conserved protein motif -designated the THAP domain - that defines a new family of cellularfactors. We have found that the THAP domain presents striking similaritieswith the site-specific DNA-binding domain (DBD) of Drosophila P elementtransposase, including a similar size, N-terminal location, andconservation of the residues that define the THAP motif, such as the C2CHsignature (Cys-Xaa(2-4)-Cys-Xaa(35-50)-Cys-Xaa(2)-His). Our resultssuggest that the THAP domain is a novel example of a DBD that is sharedbetween cellular proteins and transposases from mobile genomic parasites.
- Structure (3D structures containing this domain)
3D Structures of THAP domains in PDB
| PDB code | Main view | Title | | 2d8r |  | Solution structure of the thap domain of the human thap domain-containing protein 2 |
| 2jm3 |  | Solution structure of the thap domain from c. elegans c- terminal binding protein (ctbp) |
| 2jtg |  | Solution structure of the thap-zinc finger of thap1 |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a THAP domain in a specific node, click on it.