THUMP

THUMP
SMART accession number:SM00981
Description: The THUMP domain is named after after thiouridine synthases, methylases and PSUSs (PUBMED:11295541). The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains (PUBMED:16343540). It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets (PUBMED:11295541).
Interpro abstract (IPR004114):

The THUMP domain is shared by 4-thiouridine, pseudouridine synthases and RNA methylases [(PUBMED:11295541)] and is probably an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8. The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets [(PUBMED:11295541)].

This domain is found in the thiamine biosynthesis proteins (ThiI) (see IPR003720).

GO function:RNA binding (GO:0003723)
Family alignment:
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There are 2143 THUMP domains in 2143 proteins in SMART's nrdb database.

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