|SMART accession number:||SM00981|
|Description:||The THUMP domain is named after after thiouridine synthases, methylases and PSUSs (PUBMED:11295541). The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains (PUBMED:16343540). It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets (PUBMED:11295541).|
|Interpro abstract (IPR004114):|
The THUMP domain is shared by 4-thiouridine, pseudouridine synthases and RNA methylases [(PUBMED:11295541)] and is probably an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8. The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets [(PUBMED:11295541)].
This domain is found in the thiamine biosynthesis proteins (ThiI) (see IPR003720).
|GO function:||RNA binding (GO:0003723)|
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- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
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