TLDcdomain in TBC and LysM domain containing proteins |
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| SMART accession number: | SM00584
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| Description: |
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| Interpro abstract (IPR006571): |
TLDc is a domain of unknown function, restricted to eukaryotes, and commonly found in TBC (IPR000195) and LysM (IPR002482) domain containing proteins [(PUBMED:11779830)].
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| Family alignment: |
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There are 570
TLDc domains in 570 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Cellular role (predicted cellular role)
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Binding / catalysis: catalytic
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
- Systematic identification of novel protein domain families associated with nuclear functions.
- Genome Res. 2002; 12: 47-56
- Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a TLDc domain in a specific node, click on it.