TPK_B1_binding

Thiamin pyrophosphokinase, vitamin B1 binding domain
TPK_B1_binding
SMART accession number:SM00983
Description: Thiamin pyrophosphokinase (TPK) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis (PUBMED:11435118).
Interpro abstract (IPR007373): Thiamin pyrophosphokinase (TPK, EC 2.7.6.2) catalyzes the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [(PUBMED:11435118)].
GO process:thiamine diphosphate biosynthetic process (GO:0009229)
GO function:thiamine diphosphokinase activity (GO:0004788)
Family alignment:
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There are 725 TPK_B1_binding domains in 725 proteins in SMART's nrdb database.

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