TRASH

metallochaperone-like domain
TRASH
SMART accession number:SM00746
Description: -
Interpro abstract (IPR011017):

TRASH domain contains a well-conserved cysteine motif that may be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The precise role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated [(PUBMED:12713899)].

Family alignment:
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There are 6835 TRASH domains in 2036 proteins in SMART's nrdb database.

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