SMART: TRASH domain annotation

TRASH metallochaperone-like domain

SMART accession number:	SM00746
Description:
Interpro abstract (IPR011017):	TRASH domain contains a well-conserved cysteine motif that may be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The precise role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated [(PUBMED:12713899)].
Family alignment:	View or

There are 1917 TRASH domains in 686 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with TRASH domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Ettema TJ, Huynen MA, de Vos WM, van der Oost J
- TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance.
- Trends Biochem Sci. 2003; 28: 170-3
- Display abstract
- We describe a previously undetected domain - TRASH - containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of TRASH domains in PDB

PDB code	Main view	Title
1ffk		Crystal structure of the large ribosomal subunit from haloarcula marismortui at 2.4 angstrom resolution
1giy		Crystal structure of the ribosome at 5.5 a resolution. this file, 1giy, contains the 50s ribosome subunit. the 30s ribosome subunit, three trna, and mrna molecules are in the file 1gix
1jj2		Fully refined crystal structure of the haloarcula marismortui large ribosomal subunit at 2.4 angstrom resolution
1k73		Co-crystal structure of anisomycin bound to the 50s ribosomal subunit
1k8a		Co-crystal structure of carbomycin a bound to the 50s ribosomal subunit of haloarcula marismortui
1k9m		Co-crystal structure of tylosin bound to the 50s ribosomal subunit of haloarcula marismortui
1kc8		Co-crystal structure of blasticidin s bound to the 50s ribosomal subunit
1kd1		Co-crystal structure of spiramycin bound to the 50s ribosomal subunit of haloarcula marismortui
1kqs		The haloarcula marismortui 50s complexed with a pretranslocational intermediate in protein synthesis
1m1k		Co-crystal structure of azithromycin bound to the 50s ribosomal subunit of haloarcula marismortui
1m90		Co-crystal structure of cca-phe-caproic acid-biotin and sparsomycin bound to the 50s ribosomal subunit
1n8r		Structure of large ribosomal subunit in complex with virginiamycin m
1nji		Structure of chloramphenicol bound to the 50s ribosomal subunit
1q7y		Crystal structure of ccdap-puromycin bound at the peptidyl transferase center of the 50s ribosomal subunit
1q81		Crystal structure of minihelix with 3' puromycin bound to a- site of the 50s ribosomal subunit.
1q82		Crystal structure of cc-puromycin bound to the a-site of the 50s ribosomal subunit
1q86		Crystal structure of cca-phe-cap-biotin bound simultaneously at half occupancy to both the a-site and p- site of the the 50s ribosomal subunit.
1qvf		Structure of a deacylated trna minihelix bound to the e site of the large ribosomal subunit of haloarcula marismortui
1qvg		Structure of cca oligonucleotide bound to the trna binding sites of the large ribosomal subunit of haloarcula marismortui
1s72		Refined crystal structure of the haloarcula marismortui large ribosomal subunit at 2.4 angstrom resolution
1vq4		The structure of the transition state analogue "daa" bound to the large ribosomal subunit of haloarcula marismortui
1vq5		The structure of the transition state analogue "raa" bound to the large ribosomal subunit of haloarcula marismortui
1vq6		The structure of c-hpmn and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui
1vq7		The structure of the transition state analogue "dca" bound to the large ribosomal subunit of haloarcula marismortui
1vq8		The structure of ccda-phe-cap-bio and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui
1vq9		The structure of cca-phe-cap-bio and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui
1vqk		The structure of ccda-phe-cap-bio bound to the a site of the ribosomal subunit of haloarcula marismortui
1vql		The structure of the transition state analogue "dcsn" bound to the large ribosomal subunit of haloarcula marismortui
1vqm		The structure of the transition state analogue "dan" bound to the large ribosomal subunit of haloarcula marismortui
1vqn		The structure of cc-hpmn and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui
1vqo		The structure of ccpmn bound to the large ribosomal subunit haloarcula marismortui
1vqp		The structure of the transition state analogue "rap" bound to the large ribosomal subunit of haloarcula marismortui
1w2b		Trigger factor ribosome binding domain in complex with 50s
1yhq		Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
1yi2		Crystal structure of erythromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
1yij		Crystal structure of telithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
1yit		Crystal structure of virginiamycin m and s bound to the 50s ribosomal subunit of haloarcula marismortui
1yj9		Crystal structure of the mutant 50s ribosomal subunit of haloarcula marismortui containing a three residue deletion in l22
1yjn		Crystal structure of clindamycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
1yjw		Crystal structure of quinupristin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
1yl3		Crystal structure of 70s ribosome with thrs operator and trnas. large subunit. the coordinates for the small subunit are in the pdb entry 1yl4.
2b66		50s ribosomal subunit from a crystal structure of release factor rf1, trnas and mrna bound to the ribosome. this file contains the 50s subunit from a crystal structure of release factor rf1, trnas and mrna bound to the ribosome and is described in remark 400
2b9n		50s ribosomal subunit from a crystal structure of release factor rf2, trnas and mrna bound to the ribosome. this file contains the 50s subunit from a crystal structure of release factor rf1, trnas and mrna bound to the ribosome and is described in remark 400.
2b9p		50s ribosomal subunit from a crystal structure of the ribosome in complex with trnas and mrna with a stop codon in the a-site. this file contains the 50s subunit from a crystal structure of the ribosome in complex with trnas and mrna with a stop codon in the a-site and is described in remark 400.
2das		Solution structure of trash domain of zinc finger mym-type protein 5
2otj		13-deoxytedanolide bound to the large subunit of haloarcula marismortui
2otl		Girodazole bound to the large subunit of haloarcula marismortui
2qa4		A more complete structure of the the l7/l12 stalk of the haloarcula marismortui 50s large ribosomal subunit
2qex		Negamycin binds to the wall of the nascent chain exit tunnel of the 50s ribosomal subunit
2zkr		Structure of a mammalian ribosomal 60s subunit within an 80s complex obtained by docking homology models of the rna and proteins into an 8.7 a cryo-em map
3cc2		The refined crystal structure of the haloarcula marismortui large ribosomal subunit at 2.4 angstrom resolution with rrna sequence for the 23s rrna and genome-derived sequences for r-proteins
3cc4		Co-crystal structure of anisomycin bound to the 50s ribosomal subunit
3cc7		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation c2487u
3cce		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation u2535a
3ccj		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation c2534u
3ccl		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation u2535c. density for anisomycin is visible but not included in model.
3ccm		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2611u
3ccq		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation a2488u
3ccr		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation a2488c. density for anisomycin is visible but not included in the model.
3ccs		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2482a
3ccu		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2482c
3ccv		Structure of anisomycin resistant 50s ribosomal subunit: 23s rrna mutation g2616a
3cd6		Co-cystal of large ribosomal subunit mutant g2616a with cc- puromycin
3cma		The structure of cca and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui
3cme		The structure of ca and cca-phe-cap-bio bound to the large ribosomal subunit of haloarcula marismortui
3cpw		The structure of the antibiotic linezolid bound to the large ribosomal subunit of haloarcula marismortui
3cxc		The structure of an enhanced oxazolidinone inhibitor bound to the 50s ribosomal subunit of h. marismortui
3g4s		Co-crystal structure of tiamulin bound to the large ribosomal subunit
3g6e		Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
3g71		Co-crystal structure of bruceantin bound to the large ribosomal subunit

Links (links to other resources describing this domain)
PFAM YHS domain
INTERPRO IPR011017

PFAM	YHS domain
INTERPRO	IPR011017