TRCF

TRCF
SMART accession number:SM00982
Description: This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript.
Interpro abstract (IPR005118):

This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript.

The C-terminal region of TRCF have been shown to be necessary for RNAP displacement [(PUBMED:7876261), (PUBMED:14602898)].

GO process:DNA repair (GO:0006281)
Family alignment:
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There are 6721 TRCF domains in 6721 proteins in SMART's nrdb database.

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