TR_THYTransthyretin |
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| SMART accession number: | SM00095 |
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| Description: | - |
| Interpro abstract (IPR023416): | This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU [ (PUBMED:16098976) (PUBMED:16462750) ]. HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage [ (PUBMED:16952372) (PUBMED:8428915) ]. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence. Transthyretin (formerly prealbumin) is one of 3 thyroid hormone-binding proteins found in the blood of vertebrates [ (PUBMED:1833190) ]. It is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine (T4) [ (PUBMED:4054629) ]. It differs from the other 2 hormone-binding proteins (T4-binding globulin and albumin) in 3 distinct ways: (1) the gene is expressed at a high rate in the brain choroid plexus; (2) it is enriched in cerebrospinal fluid; and (3) no genetically caused absence has been observed, suggesting an essential role in brain function, distinct from that played in the bloodstream [ (PUBMED:1833190) ]. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain [ (PUBMED:1833190) ]. |
| Family alignment: |
There are 3116 TR_THY domains in 3113 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing TR_THY domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with TR_THY domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing TR_THY domain in the selected taxonomic class.
- Disease (disease genes where sequence variants are found in this domain)
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SwissProt sequences and OMIM curated human diseases associated with missense mutations within the TR_THY domain.
Protein Disease Transthyretin (P02766) (SMART) OMIM:176300: Amyloid neuropathy, familial, several allelic types ; [Dystransthyretinemic hyperthyroxinemia]; Amyloidosis, senile systemic ; Carpal tunnel syndrome, familial - Metabolism (metabolic pathways involving proteins which contain this domain)
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% proteins involved KEGG pathway ID Description 16.67 map05218 Melanoma 16.67 map05219 Bladder cancer 16.67 map04520 Adherens junction 16.67 map05216 Thyroid cancer 16.67 map05213 Endometrial cancer 16.67 map04514 Cell adhesion molecules (CAMs) This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with TR_THY domain which could be assigned to a KEGG orthologous group, and not all proteins containing TR_THY domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of TR_THY domains in PDB
PDB code Main view Title 1bm7 
HUMAN TRANSTHYRETIN (PREALBUMIN) COMPLEX WITH FLUFENAMIC ACID (2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID) 1bmz 
HUMAN TRANSTHYRETIN (PREALBUMIN) 1bz8 
TRANSTHYRETIN (DEL VAL122) 1bzd 
TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION 1bze 
TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION 1dvq 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN 1dvs 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH RESVERATROL 1dvt 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH FLURBIPROFEN 1dvu 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DIBENZOFURAN-4,6-DICARBOXYLIC ACID 1dvx 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DICLOFENAC 1dvy 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH N-(M-TRIFLUOROMETHYLPHENYL) PHENOXAZINE-4,6-DICARBOXYLIC ACID 1dvz 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH O-TRIFLUOROMETHYLPHENYL ANTHRANILIC ACID 1e3f 
Structure of human transthyretin complexed with bromophenols: a new mode of binding 1e4h 
Structure of human transthyretin complexed with bromophenols: a new mode of binding 1e5a 
Structure of human transthyretin complexed with bromophenols: a new mode of binding 1eta 
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION 1etb 
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION 1f41 
CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN AT 1.5A RESOLUTION 1f86 
TRANSTHYRETIN THR119MET PROTEIN STABILISATION 1fh2 
TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS 1fhn 
TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS 1g1o 
CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S 1gke 
RAT TRANSTHYRETIN 1gko 
An Engineered Transthyretin Monomer that is Non-amyloidogenic - Unless Partially Denatured 1ict 
MONOCLINIC FORM OF HUMAN TRANSTHYRETIN COMPLEXED WITH THYROXINE (T4) 1ie4 
RAT TRANSTHYRETIN COMPLEX WITH THYROXINE (T4) 1iii 
CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT ROOM TEMPERATURE 1iik 
CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR Y114C-DATA COLLECTED AT CRYO TEMPERATURE 1ijn 
Crystal structure of the transthyretin mutant TTR C10A/Y114C 1kgi 
Rat transthyretin (also called prealbumin) complex with 3,3',5,5'-tetraiodothyroacetic acid (t4ac) 1kgj 
Rat transthyretin (also called prealbumin) complex with 3',5'-dibromoflavone (EMD21388) 1oo2 
Crystal structure of transthyretin from Sparus aurata 1qab 
The structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of RBP 1qwh 
a covalent dimer of transthyretin that affects the amyloid pathway 1rlb 
RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN 1sn0 
Crystal Structure Of Sea Bream Transthyretin in complex with thyroxine At 1.9A Resolution 1sn2 
Crystal Structure of Sea Bream Transthyretin at 1.90A Resolution 1sn5 
Crystal Structure of Sea Bream Transthyretin in complex with Triiodothyronine at 1.90A Resolution 1sok 
Crystal structure of the transthyretin mutant A108Y/L110E solved in space group p21212 1soq 
Crystal structure of the transthyretin mutant A108Y/L110E solved in space group C2 1tfp 
TRANSTHYRETIN (FORMERLY KNOWN AS PREALBUMIN) 1tha 
MECHANISM OF MOLECULAR RECOGNITION. STRUCTURAL ASPECTS OF 3,3'-DIIODO-L-THYRONINE BINDING TO HUMAN SERUM TRANSTHYRETIN 1thc 
CRYSTAL STRUCTURE DETERMINATION AT 2.3A OF HUMAN TRANSTHYRETIN-3',5'-DIBROMO-2',4,4',6-TETRA-HYDROXYAURONE COMPLEX 1tlm 
STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX 1tsh 
TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION 1tt6 
The orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol 1tta 
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION 1ttb 
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION 1ttc 
THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION 1ttr 
TRANSTHYRETIN-V/122/I CARDIOMYOPATHIC MUTANT 1tyr 
TRANSTHYRETIN COMPLEX WITH RETINOIC ACID 1tz8 
The monoclinic crystal struture of transthyretin in complex with diethylstilbestrol 1u21 
transthyretin with tethered inhibitor on one monomer. 1x7s 
The X-ray crystallographic structure of the amyloidogenic variant TTR Tyr78Phe 1x7t 
Structure of TTR R104H: a non-amyloidogenic variant with protective clinical effects 1y1d 
Crystal structure of transthyretin in complex with iododiflunisal 1z7j 
Human transthyretin (also called prealbumin) complex with 3, 3',5,5'-tetraiodothyroacetic acid (t4ac) 1zcr 
Crystal structure of human Transthyretin with bound iodide 1zd6 
Crystal structure of human transthyretin with bound chloride 2b14 
The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Leu 55 Pro 2b15 
The crystal structure of 2,4-dinitrophenol in complex with human transthyretin 2b16 
The crystal structure of 2,4-dinitrophenol in complex with the amyloidogenic variant Transthyretin Tyr78Phe 2b77 
Human transthyretin (TTR) complexed with Diflunisal analogues- TTR.2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACID 2b9a 
Human transthyretin (TTR) complexed with diflunisal analogues- TTR.3',5'-difluorobiphenyl-4-carboxylic acid 2f7i 
Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid 2f8i 
Human transthyretin (TTR) complexed with Benzoxazole 2fbr 
Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (4 carbon linker) 2flm 
Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker) 2g2n 
Crystal Structure of E.coli transthyretin-related protein with bound Zn 2g2p 
Crystal Structure of E.coli transthyretin-related protein with bound Zn and Br 2g3x 
Crystal structure of Transthyretin mutant I84S at acidic pH 2g3z 
Crystal structure of Transthyretin mutant I84A at low pH 2g4e 
Crystal structure of transthyretin mutant I84A at neutral pH 2g4g 
Crystal structure of human transthyretin at pH 4.6 2g5u 
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl 2g9k 
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-2',3,3',4',5-Pentachlorobiphenyl 2gab 
Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl 2gpz 
Transthyretin-like protein from Salmonella dublin 2h0e 
Crystal Structure of PucM in the absence of substrate 2h0f 
Crystal Structure of PucM in the presence of 8-azaxanthine 2h0j 
Crystal structure of PucM in the presence of 5,6-diaminouracil 2h1x 
Crystal structure of 5-hydroxyisourate Hydrolase (formerly known as TRP, Transthyretin Related Protein) 2h4e 
Crystal structure of Cys10 sulfonated transthyretin 2h6u 
Crystal structure of 5-hydroxyisourate hydrolase (formerly known as TRP, transthyretin related protein) 2igl 
Crystal Structure of E. coli YEDX, a transthyretin related protein 2noy 
Crystal structure of transthyretin mutant I84S at PH 7.5 2pab 
STRUCTURE OF PREALBUMIN, SECONDARY, TERTIARY AND QUATERNARY INTERACTIONS DETERMINED BY FOURIER REFINEMENT AT 1.8 ANGSTROMS 2qel 
Crystal structure of the highly amyloidogenic transthyretin mutant TTR G53S/E54D/L55S- heated protein 2qgb 
Human transthyretin (TTR) in Apo-form 2qgc 
Human transthyretin (TTR) complexed with 2-(3,5-Dimethyl-4-hydroxyphenyl)benzoxazole 2qgd 
Human transthyretin (TTR) complexed with 2-(3,5-Dibromo-4-hydroxyphenyl)benzoxazole 2qge 
Human transthyretin (TTR) complexed with 2-(3,5-Dimethylphenyl)benzoxazole 2qpf 
Crystal Structure of Mouse Transthyretin 2rox 
TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH THYROXINE (T4) 2roy 
TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE 2trh 
TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION 2try 
TERTIARY STRUCTURES OF THREE AMYLOIDOGENIC TRANSTHYRETIN VARIANTS AND IMPLICATIONS FOR AMYLOID FIBRIL FORMATION 2wqa 
Complex of TTR and RBP4 and Oleic Acid 3a4d 
Crystal structure of Human Transthyretin (wild-type) 3a4e 
Crystal structure of Human Transthyretin (E54G) 3a4f 
Crystal Structure of Human Transthyretin (E54K) 3b56 
Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid 3bsz 
Crystal structure of the transthyretin-retinol binding protein-Fab complex 3bt0 
Crystal structure of transthyretin variant V20S 3cbr 
Crystal structure of human Transthyretin (TTR) at pH3.5 3cfm 
Crystal structure of the apo form of human wild-type transthyretin 3cfn 
Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate 3cfq 
Crystal structure of human wild-type transthyretin in complex with diclofenac 3cft 
Crystal structure of human transthyretin in complex with 1-amino-5-naphthalene sulfonate 3cn0 
Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene 3cn1 
Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxystilbene 3cn2 
Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxybiphenyl 3cn3 
Human transthyretin (TTR) in complex with 1,3-Dibromo-2-hydroxy-5-phenoxybenzene 3cn4 
Human transthyretin (TTR) in complex with N-(3,5-Dibromo-4-hydroxyphenyl)benzamide 3cxf 
Crystal structure of transthyretin variant Y114H 3d2t 
Human transthyretin (ttr) complexed with diflunisal 3d7p 
Crystal structure of human Transthyretin (TTR) at pH 4.0 3dgd 
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 3did 
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 soaked 3djr 
CRYSTAL STRUCTURE OF TRANSTHYRETIN VARIANT L58H at neutral pH 3djs 
Crystal structure of transthyretin variant L58H at acidic pH 3djt 
Crystal structure of transthyretin variant V30M at acidic pH 3djz 
Crystal structure of transthyretin variant L55P at neutral pH 3dk0 
Crystal structure of transthyretin variant L55P at acidic pH 3dk2 
Crystal structure of transthyretin variant Y114H at acidic pH 3do4 
Crystal structure of transthyretin variant T60A at acidic pH 3esn 
Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide 3eso 
Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,5-dichlorobenzamide 3esp 
Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-3,5-dimethyl-4-hydroxybenzamide 3fc8 
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe 3fcb 
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH 3glz 
Human Transthyretin (TTR) complexed with(E)-3-(2-(trifluoromethyl)benzylideneaminooxy)propanoic acid (inhibitor 11) 3gps 
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 5.5 3grb 
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 6.5 3grg 
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 7.5 3gs0 
Human transthyretin (TTR) complexed with (S)-3-(9H-fluoren-9-ylideneaminooxy)-2-methylpropanoic acid (inhibitor 16) 3gs4 
Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid (inhibitor 15) 3gs7 
Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13) 3hj0 
Transthyretin in complex with a covalent small molecule kinetic stabilizer 3i9a 
Crystal structure of human transthyretin variant A25T - #1 3i9i 
Crystal structure of human transthyretin variant A25T - #2 3i9p 
Crystal structure of human transthyretin - wild type 3imr 
Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol 3ims 
Transthyretin in complex with 2,6-dibromo-4-(2,6-dichlorophenethyl)phenol 3imt 
Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromophenol 3imu 
Transthyretin in complex with (E)-4-(3-aminostyryl)-2,6-dibromoaniline 3imv 
Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromoaniline 3imw 
Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dimethoxystyryl)aniline 3ipb 
Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (11 carbon linker). 3ipe 
Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker). 3iwu 
Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase 3iwv 
Crystal structure of Y116T mutant of 5-HYDROXYISOURATE HYDROLASE (TRP) 3kgs 
V30M mutant human transthyretin (TTR) (apoV30M) pH 7.5 3kgt 
V30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.5 3kgu 
Wild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.5 3m1o 
Human Transthyretin (TTR) complexed with 2-((3,5-dichloro-4-hydroxyphenyl)amino)benzoic acid 3nee 
Wild type human transthyretin (TTR) complexed with GC-1 (TTRwt:GC-1) 3neo 
Wild type human transthyretin (TTR) complexed with GC-24 (TTRwt:GC-24) 3nes 
V30M mutant human transthyretin (TTR) complexed with GC-1 (V30M:GC-1) 3nex 
V30M mutant human transthyretin (TTR) complexed with GC-24 (V30M:GC-24) 3ng5 
Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG) 3ozk 
Crystal structure of human transthyretin variant A25T in complex with thyroxine (T4) 3ozl 
Crystal structure of human transthyretin variant A25T in complex with flufenamic acid. 3p3r 
Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone 3p3s 
Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one 3p3t 
Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole 3p3u 
Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole 3q1e 
Crystal structure of Y116T/I16A double mutant of 5-hydroxyisourate hydrolase in complex with T4 3ssg 
Structure of transthyretin L55P in complex with Zn 3tct 
Structure of wild-type TTR in complex with tafamidis 3tfb 
Transthyretin natural mutant A25T 3u2i 
X-ray crystal structure of human Transthyretin at room temperature 3u2j 
Neutron crystal structure of human Transthyretin 3w3b 
Crystal structure of wild-type human transthyretin 4abq 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-1 4abu 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-2 4abv 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-3 4abw 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-6 4ac2 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-7 4ac4 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-18 4act 
CRYSTAL STRUCTURE OF TRANSTHYRETIN IN COMPLEX WITH LIGAND C-17 4ank 
Crystallographic study of novel transthyretin ligands exhibiting negative-cooperativity between two T4 binding sites. 4d7b 
4D7B 4der 
Crystal Structure of the Wild Type TTR Binding Apigenin (TTRwt:API) 4des 
Crystal Structure of the Wild Type TTR Binding Chrysin (TTRwt:CHR) 4det 
Crystal Structure of the Wild Type TTR Binding Kaempferol (TTRwt:KAE) 4deu 
Crystal Structure of the Wild Type TTR Binding Naringenin (TTRwt:NAR) 4dew 
Crystal Structure of the Wild Type TTR Binding Luteolin (TTRwt:LUT) 4fi6 
Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide 4fi7 
Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide 4fi8 
Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide 4hiq 
The Structure of V122I Mutant Transthyretin in Complex with AG10 4his 
The Structure of V122I Mutant Transthyretin in Complex with Tafamidis 4hjs 
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide 4hjt 
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide 4hju 
Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide 4i85 
Crystal structure of transthyretin in complex with CHF5074 at neutral pH 4i87 
Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH 4i89 
Crystal structure of transthyretin in complex with diflunisal at acidic pH 4iiz 
Crystal structure of wild-type human transthyretin in complex with lumiracoxib 4ik6 
Crystal structure of human transthyretin in complex with lumiracoxib 4ik7 
Crystal structure of human transthyretin in complex with indomethacin 4iki 
Crystal structure of wild-type human transthyretin in complex with indomethacin 4ikj 
Crystal structure of wild-type human transthyretin in complex with sulindac 4ikk 
Crystal structure of wild-type human transthyretin in complex with sulindac 4ikl 
Crystal structure of wild-type human transthyretin in complex with sulindac 4ky2 
Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one 4l1s 
Covalent modification of transthyretin K15 by yielding the fluorescent conjugate (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzamide 4l1t 
Transthyretin in complex with (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoic acid 4mas 
High Resolution Structure of Wild Type Human Transthyretin in Complex with 3,3',5,5'-tetrachloro-[1,1'-biphenyl]-4,4'diol 4mrb 
Wild Type Human Transthyretin pH 7.5 4mrc 
Human Transthyretin Ser52Pro Mutant 4n85 
Crystal structure of human transthyretin 4n86 
Crystal structure of human transthyretin complexed with glabridin 4n87 
Crystal structure of V30M mutant human transthyretin complexed with glabridin 4pm1 
4PM1 4pme 
4PME 4pmf 
4PMF 4pvl 
4PVL 4pvm 
4PVM 4pvn 
4PVN 4pwe 
4PWE 4pwf 
4PWF 4pwg 
4PWG 4pwh 
4PWH 4pwi 
4PWI 4pwj 
4PWJ 4pwk 
4PWK 4q14 
Crystal structure of 5-hydroxyisourate hydrolase from Brucella melitensis 4qrf 
4QRF 4qxv 
4QXV 4qya 
4QYA 4tkw 
4TKW 4tl4 
4TL4 4tl5 
4TL5 4tlk 
4TLK 4tls 
4TLS 4tlt 
4TLT 4tlu 
4TLU 4tm9 
4TM9 4tne 
4TNE 4tnf 
4TNF 4tng 
4TNG 4tq8 
4TQ8 4tqh 
4TQH 4tqi 
4TQI 4tqp 
4TQP 4wnj 
4WNJ 4wns 
4WNS 4wo0 
4WO0 4y9b 
4Y9B 4y9c 
4Y9C 4y9e 
4Y9E 4y9f 
4Y9F 4y9g 
4Y9G 4ydm 
4YDM 4ydn 
4YDN 5a6i 
5A6I 5aks 
5AKS 5akt 
5AKT 5akv 
5AKV 5al0 
5AL0 5al8 
5AL8 5ayt 
5AYT 5boj 
5BOJ 5clx 
5CLX 5cly 
5CLY 5clz 
5CLZ 5cm1 
5CM1 5cn3 
5CN3 5cnh 
5CNH 5cr1 
5CR1 5dej 
5DEJ 5dwp 
5DWP 5e23 
5E23 5e4a 
5E4A 5e4o 
5E4O 5en3 
5EN3 5ezp 
5EZP 5fo2 
5FO2 5hjg 
5HJG 5ihh 
5IHH 5jid 
5JID 5jim 
5JIM 5jiq 
5JIQ 5k1j 
5K1J 5k1n 
5K1N 5l4f 
5L4F 5l4i 
5L4I 5l4j 
5L4J 5l4m 
5L4M 5ttr 
LEU 55 PRO TRANSTHYRETIN CRYSTAL STRUCTURE - Links (links to other resources describing this domain)
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INTERPRO IPR023416 PROSITE PS00769