Tbf5

Transcription factor TFIIH complex subunit Tfb5
Tbf5
SMART accession number:SM01395
Description: This family is a component of the general transcription and DNA repair factor IIH. TFB5 has been shown to be required for efficient recruitment of TFIIH to a promoter PMID:15220919.
Interpro abstract (IPR009400):

This entry represents TTDA/Tfb5 subunit of TFIIH basal transcription factor complex. These proteins have a structural motif consisting of a 2-layer sandwich structure with an alpha/beta plait topology. Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage in most organisms.

Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair. The TFIIH multiprotein complex consists of a 7-subunit core (XPB, p62, p52, p44, p34, and TTDA) that is associated with a 3-subunit CDK-activating kinase module (MAT1, cyclin H and Cdk7) [(PUBMED:21592869)].

In humans, defects in TTDA cause the trichothiodystrophy photosensitive (TTDP), an autosomal recessive disease characterised by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER) defect [(PUBMED:15220921)].

GO process:regulation of transcription, DNA-templated (GO:0006355), nucleotide-excision repair (GO:0006289)
GO component:core TFIIH complex (GO:0000439)
Family alignment:
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There are 1061 Tbf5 domains in 1059 proteins in SMART's nrdb database.

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