Telo_bind

Telomeric single stranded DNA binding POT1/CDC13
Telo_bind
SMART accession number:SM00976
Description: The telomere-binding protein forms a heterodimer in ciliates consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang. Alpha subunit consists of 3 structural domains, all with the same beta-barrel OB fold.
Interpro abstract (IPR011564):

This domain binds single stranded telomeric DNA and adopts an OB fold [(PUBMED:11935027)]. It includes the proteins POT1 and Cdc13 which have been shown to regulate telomere length, replication and capping [(PUBMED:11230149), (PUBMED:18066078), (PUBMED:16943437)]. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [(PUBMED:1239117), (PUBMED:19228335)].

GO process:telomere maintenance (GO:0000723)
GO component:nuclear chromosome, telomeric region (GO:0000784)
GO function:DNA binding (GO:0003677)
Family alignment:
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There are 329 Telo_bind domains in 329 proteins in SMART's nrdb database.

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