Telo_bindTelomeric single stranded DNA binding POT1/CDC13
|SMART accession number:||SM00976|
|Description:||The telomere-binding protein forms a heterodimer in ciliates consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang. Alpha subunit consists of 3 structural domains, all with the same beta-barrel OB fold.|
|Interpro abstract (IPR011564):|
This domain binds single stranded telomeric DNA and adopts an OB fold [(PUBMED:11935027)]. It includes the proteins POT1 and Cdc13 which have been shown to regulate telomere length, replication and capping [(PUBMED:11230149), (PUBMED:18066078), (PUBMED:16943437)]. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [(PUBMED:1239117), (PUBMED:19228335)].
|GO process:||telomere maintenance (GO:0000723)|
|GO component:||nuclear chromosome, telomeric region (GO:0000784)|
|GO function:||DNA binding (GO:0003677)|
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