Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

Thiol-ester_cl Alpha-macro-globulin thiol-ester bond-forming region

SMART accession number:	SM01419
Description:	This short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 0 Thiol-ester_cl domains in 0 proteins in SMART's nrdb database.

Click on the following links for more information.

Structure (3D structures containing this domain)

3D Structures of Thiol-ester_cl domains in PDB

PDB code	Main view	Title
1c3d		X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2
1ghq		CR2-C3D COMPLEX STRUCTURE
1hzf		C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A
1w2s		Solution structure of CR2 SCR 1-2 in its complex with C3d by X-ray scattering
2a73		Human Complement Component C3
2b39		Structure of mammalian C3 with an intact thioester at 3A resolution
2gox		Crystal structure of Efb-C / C3d Complex
2i07		Human Complement Component C3b
2icf		CRIg bound to C3b
2noj		Crystal structure of Ehp / C3d complex
2pn5		Crystal Structure of TEP1r
2wii		Complement C3b in complex with factor H domains 1-4
2win		C3 convertase (C3bBb) stabilized by SCIN
2wy7		Staphylococcus aureus complement subversion protein Sbi-IV in complex with complement fragment C3d revealing an alternative binding mode
2wy8		Staphylococcus aureus complement subversion protein Sbi-IV in complex with complement fragment C3d
2xqw		Structure of Factor H domains 19-20 in complex with complement C3d
2xwb		Crystal Structure of Complement C3b in complex with Factors B and D
2xwj		Crystal Structure of Complement C3b in Complex with Factor B
3d5r		Crystal Structure of Efb-C (N138A) / C3d Complex
3d5s		Crystal Structure of Efb-C (R131A) / C3d Complex
3g6j		C3b in complex with a C3b specific Fab
3l5n		Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b
3oed		The structure of the complex between complement receptor CR2 and its ligand complement fragment C3d
3oxu		Complement components factor H CCP19-20 and C3d in complex
3prx		Structure of Complement C5 in Complex with CVF and SSL7
3pvm		Structure of Complement C5 in Complex with CVF
3rj3		Complement components factor H CCP19-20 (S1191L mutant) and C3D in complex
4acq		Alpha-2 Macroglobulin
4d94		Crystal Structure of TEP1r
4fxg		Complement C4 in complex with MASP-2
4fxk		Human complement C4
4lnv		Crystal Structure of TEP1s
4m76		Integrin I domain of complement receptor 3 in complex with C3d
4ont		4ONT
4rtd		4RTD
4u48		4U48
4u59		4U59
4xam		4XAM
4zh1		4ZH1
4ziq		4ZIQ
4ziu		4ZIU
5a42		5A42
5fo7		5FO7
5fo8		5FO8
5fo9		5FO9
5foa		5FOA
5fob		5FOB
5jpm		5JPM
5jpn		5JPN
5jtw		5JTW

Links (links to other resources describing this domain)

PFAM	Thiol-ester_cl

Send comments to Ivica Letunic