Thymopoietin

Thymopoietin
SMART accession number:SM01261
Description: Short protein of 49 amino acid isolated from bovine spleen cells (PUBMED:7306506). Thymopoietins (TMPOs) are a group of ubiquitously expressed nuclear proteins. They are suggested to play an important role in nuclear envelope organisation and cell cycle control (PUBMED:10430029).
Interpro abstract (IPR013146):

The LEM (LAP2, emerin, MAN1) domain is a globular module of approximately 40 amino acids, which is mostly found in the nucleoplasmic portions of metazoan inner nuclear membrane proteins. The LEM domain has been shown to mediate binding to BAF (barrier-to-autointegration factor) and BAF-DNA complexes.

All LAP2 isoforms also share an N-terminal segment composed of a LEM domain that is connected to a highly divergent LEM-like domain by a highly flexible 60- residue linker. The LEM-like globular domain has the same size and structural fold as the LEM domain, but has been shown to bind directly to DNA [(PUBMED:10671519), (PUBMED:11500367), (PUBMED:11435115)].

This entry represents the LEM-like domain.

GO function:DNA binding (GO:0003677)
Family alignment:
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There are 794 Thymopoietin domains in 783 proteins in SMART's nrdb database.

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