Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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UAS

SMART accession number:	SM00594
Description:
Interpro abstract (IPR006577):	UAS is a domain of unknown function found in FAF1 proteins (FAS-associated factor 1) and in other proteins, many of which are described as having no known function.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 342 UAS domains in 341 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a UAS domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with UAS domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
  • Systematic identification of novel protein domain families associated with nuclear functions.
  • Genome Res. 2002; 12: 47-56
  • Display abstract

  • A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.

• Structure (3D structures containing this domain)

• 3D Structures of UAS domains in PDB

  PDB code	Main view	Title
  2dlx		Solution structure of the uas domain of human ubx domain- containing protein 7
  2ec4		Solution structure of the uas domain from human fas- associated factor 1

• Links (links to other resources describing this domain)

• INTERPRO	IPR006577

Send comments to Ivica Letunic