Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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UBA_e1_C Ubiquitin-activating enzyme e1 C-terminal domain

SMART accession number:	SM00985
Description:	This presumed domain found at the C terminus of Ubiquitin-activating enzyme e1 proteins is functionally uncharacterised.
Interpro abstract (IPR018965):	This domain is found at the C terminus of Ubiquitin-activating enzyme E1 proteins. It binds to E2 enzymes [ (PUBMED:18662542) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 2712 UBA_e1_C domains in 2709 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing UBA_e1_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with UBA_e1_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing UBA_e1_C domain in the selected taxonomic class.

• Structure (3D structures containing this domain)

• 3D Structures of UBA_e1_C domains in PDB

  PDB code	Main view	Title
  3cmm		Crystal Structure of the Uba1-Ubiquitin Complex
  4ii2		Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg
  4ii3		Crystal structure of S. pombe Ubiquitin activating enzyme 1 (Uba1) in complex with ubiquitin and ATP/Mg
  4nnj		Crystal structure of Uba1 in complex with ubiquitin-AMP and thioesterified ubiquitin

• Links (links to other resources describing this domain)

• INTERPRO	IPR018965
  PFAM	UBA_e1_C

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