UTG

Uteroglobin
UTG
SMART accession number:SM00096
Description:
Interpro abstract (IPR006039):

Uteroglobin (or blastokinin) is a mammalian steroid-inducible secreted protein originally isolated from the uterus of rabbits during early pregnancy. The mucosal epithelia of several organs that communicate with the external environment express uteroglobin. Its tissue-specific expression is regulated by steroid hormones, and is augmented in the uterus by non-steroidal prolactin. Uteroglobin may be a multi-functional protein with anti-inflammatory/immunomodulatory properties, acting to inhibit phospholipase A2 activity, and binding to (and possibly sequestering) several hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids and prostaglandins. In addition, uteroglobin has anti-chemotactic, anti-allergic, anti-tumourigenic and embryo growth-stimulatory properties. Uteroglobin may have a homeostatic role against oxidative damage, inflammation, autoimmunity and cancer [(PUBMED:17916741), (PUBMED:17928103), (PUBMED:11193760), (PUBMED:7770456)]. Uteroglobin consists of a disulphide-linked dimer of two identical polypeptides, each polypeptide being composed of four helices. It is a member of the secretoglobin superfamily.

This entry represents uteroglobin proteins from several mammalian species, as well as other secretoglobins, such as lipophilin B [(PUBMED:17163411)], prostatic steroid-binding protein [(PUBMED:17641022)] and the related allergen Fel d 1 (Felis domesticus allergen 1) [(PUBMED:17543334)].

Family alignment:
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There are 109 UTG domains in 109 proteins in SMART's nrdb database.

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