Domain present in VPS-27, Hrs and STAM
SMART accession number:SM00288
Description: Unpublished observations. Domain of unknown function.
Interpro abstract (IPR002014):

The VHS domain is an about 150 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. The VHS domain is found at the N- termini of proteins associated with endocytocis and/or vesicular trafficking, often in association with other domains like FYVE, SH3 or TAM [ (PUBMED:9600884) (PUBMED:9872381) ]. The VHS domain of Hrs makes both intra- and intermolecular interactions with FYVE domains and it has been proposed that it might as well interact with other domains. The VHS domain might function as a multipurpose docking adapter that localizes proteins to the membrane through interactions with the membrane and/or the endocytic machinery [ (PUBMED:10693761) (PUBMED:10985773) ].

Resolution of the crystal structure of the VHS domain of Drosophila Hrs and human Tom1 revealed that it consists of eight helices arranged in a superhelix [ (PUBMED:10693761) (PUBMED:10985773) ].

GO process:intracellular protein transport (GO:0006886)
Family alignment:
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There are 6698 VHS domains in 6696 proteins in SMART's nrdb database.

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