VHSDomain present in VPS-27, Hrs and STAM
|SMART accession number:||SM00288|
|Description:||Unpublished observations. Domain of unknown function.|
|Interpro abstract (IPR018205):|
The VHS domain is a ~140 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. Based on regions surrounding the domain, VHS-proteins can be divided into 4 groups [(PUBMED:11911875)]:
Resolution of the crystal structure of the VHS domain of Drosophila Hrs and human Tom1 revealed that it consists of eight helices arranged in a double-layer superhelix [(PUBMED:10693761)]. The existence of conserved patches of residues on the domain surface suggests that VHS domains may be involved in protein-protein recognition and docking. Overall, sequence similarity is low (approx 25%) amongst domain family members. In this entry, the domain is found in ADP-ribosylation factor-binding proteins and Hepatocyte growth factor-regulated tyrosine kinase substrates as well as vacuolar protein-sorting machinery proteins, amongst others.
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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