Vault protein Inter-alpha-Trypsin domain
SMART accession number:SM00609
Description: -
Interpro abstract (IPR013694):

Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition [(PUBMED:14744536)]. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N terminus of a von Willebrand factor type A domain (IPR002035) in ITI heavy chains (ITIHs) and their precursors.

Family alignment:
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There are 688 VIT domains in 684 proteins in SMART's nrdb database.

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