Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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VIT Vault protein Inter-alpha-Trypsin domain

SMART accession number:	SM00609
Description:
Interpro abstract (IPR013694):	Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains. ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition [(PUBMED:14744536)]. The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N terminus of a von Willebrand factor type A domain (IPR002035) in ITI heavy chains (ITIHs) and their precursors.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 206 VIT domains in 204 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a VIT domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with VIT domain is also avaliable.

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  Go to specific node: Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Links (links to other resources describing this domain)

• INTERPRO	IPR013694

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