Wiskott Aldrich syndrome homology region 2
SMART accession number:SM00246
Description: Wiskott Aldrich syndrome homology region 2 / actin-binding motif
Interpro abstract (IPR003124):

The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognised as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain and with the CRIB domain, and the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments [(PUBMED:11434350), (PUBMED:11911886)].

GO function:actin binding (GO:0003779)
Family alignment:
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There are 1040 WH2 domains in 734 proteins in SMART's nrdb database.

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