WIF

Wnt-inhibitory factor-1 like domain
WIF
SMART accession number:SM00469
Description: Occurs as extracellular domain in metazoan Ryk receptor tyrosine kinases. C. elegans Ryk is required for cell-cuticle recognition. WIF-1 binds to Wnt and inhibits its activity.
Interpro abstract (IPR003306): This entry represents the WIF domain, and is found in the RYK tyrosine kinase receptors and WIF the Wnt-inhibitory-factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge. This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt [(PUBMED:10637605)].
Family alignment:
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There are 120 WIF domains in 120 proteins in SMART's nrdb database.

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