Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

WWE Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis.

SMART accession number:	SM00678
Description:
Interpro abstract (IPR018123):	The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor [(PUBMED:16271883)]. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins [(PUBMED:11343911)].
GO function:	zinc ion binding (GO:0008270)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 257 WWE domains in 153 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a WWE domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with WWE domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: transcription
  Binding / catalysis: unknown

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Aravind L
  • The WWE domain: a common interaction module in protein ubiquitination andADP ribosylation.
  • Trends Biochem Sci. 2001; 26: 273-5
  • Display abstract

  • Sequence profile analysis was used to detect a conserved globular domainin several proteins including deltex, Trip12 and poly-ADP-ribosepolymerase homologs. It was named the WWE domain after its most conservedresidues and is predicted to mediate specific protein-protein interactionsin ubiquitin and ADP-ribose conjugation systems.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 100.00 map04330 Notch signaling pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with WWE domain which could be assigned to a KEGG orthologous group, and not all proteins containing WWE domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of WWE domains in PDB

  PDB code	Main view	Title
  1ujr		Solution structure of wwe domain in bab28015
  2a90		Crystal structure of the tandem wwe domain of drosophila deltex

• Links (links to other resources describing this domain)

• INTERPRO	IPR018123

Send comments to Ivica Letunic