XPGIXeroderma pigmentosum G I-region
|SMART accession number:||SM00484|
|Description:||domain in nucleases|
|Interpro abstract (IPR006086):|
This entry represents a protein domain found on Xeroderma Pigmentosum Complementation Group G (XPG) protein [(PUBMED:8206890)]. The function of the internal XPG (XPG-I) domain contains many of cysteine and glutamate amino acid residues that are frequently found in various enzyme active sites, DNA nucleases. The I domain, together with the N-terminal forms the catalytic domain that contains the active site [(PUBMED:14726017)].
Proteins in this entry are endonucleases that cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
|GO function:||nuclease activity (GO:0004518)|
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