Xeroderma pigmentosum G I-region
SMART accession number:SM00484
Description: domain in nucleases
Interpro abstract (IPR006086):

This entry represents a protein domain found on Xeroderma Pigmentosum Complementation Group G (XPG) protein [(PUBMED:8206890)]. The function of the internal XPG (XPG-I) domain contains many of cysteine and glutamate amino acid residues that are frequently found in various enzyme active sites, DNA nucleases. The I domain, together with the N-terminal forms the catalytic domain that contains the active site [(PUBMED:14726017)].

Proteins in this entry are endonucleases that cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

GO function:nuclease activity (GO:0004518)
Family alignment:
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There are 2242 XPGI domains in 2241 proteins in SMART's nrdb database.

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