XPGI

Xeroderma pigmentosum G I-region
XPGI
SMART accession number:SM00484
Description: domain in nucleases
Interpro abstract (IPR006086):

This entry represents endonucleases that cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities. Cleaves the junction between single and double-stranded regions of flap DNA. The endonuclease binds 2 magnesium ions per subunit. which probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.

GO process:DNA repair (GO:0006281)
GO function:nuclease activity (GO:0004518)
Family alignment:
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There are 793 XPGI domains in 792 proteins in SMART's nrdb database.

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