This domain is found in proteins of the YL1 family. These proteins have been shown to be DNA-binding and may be a transcription factor. This domain is found in proteins that are not YL1 proteins.
This domain is found at the C terminus in proteins of the Vps72/YL1 family [ (PUBMED:7702631) ]. These proteins are involved in chromatin remodelling [ (PUBMED:23580526) (PUBMED:15528408) ]. This domain is also found in proteins that do not belong to the Vps72/YL1 family.
Family alignment:
There are 2828 YL1_C domains in 2824 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing YL1_C domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with YL1_C domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing YL1_C domain in the selected taxonomic class.
Molecular cloning of a novel human cDNA on chromosome 1q21 and its mousehomolog encoding a nuclear protein with DNA-binding ability.
Biochem Biophys Res Commun. 1995; 208: 999-1007
Display abstract
We previously reported that human chromosome 1q21 or 1q23-q24 carries atransformation suppressor gene(s) for Kirsten sarcoma virus-transformedNIH3T3 cells. In this study, we have isolated a novel human cDNA on 1q21(designated as YL-1) as a candidate, then cloned its mouse homolog. Humanand mouse YL-1 cDNA shared 96% in amino acid homology and presumablyencoded a transcription factor-like polypeptide. An analysis using aspecific antibody revealed the nuclear localization of YL-1 protein. Thebacterially expressed YL-1 could bind to DNA. Thus, YL-1 protein possiblyfunctions as a transcriptional regulator.
Links (links to other resources describing this domain)
