The Zasp-like motif is a short (26 amino acid) motif that is frequently found in association with PDZ domains in a number of cytoskeletal and muscle proteins, such as Zasp [ (PUBMED:10427098) ].
Family alignment:
There are 3289 ZM domains in 3100 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing ZM domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with ZM domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing ZM domain in the selected taxonomic class.
ZASP: a new Z-band alternatively spliced PDZ-motif protein.
J Cell Biol. 1999; 146: 465-75
Display abstract
PDZ motifs are modular protein-protein interaction domains, consisting of 80-120 amino acid residues, whose function appears to be the direction of intracellular proteins to multiprotein complexes. In skeletal muscle, there are a few known PDZ-domain proteins, which include neuronal nitric oxide synthase and syntrophin, both of which are components of the dystrophin complex, and actinin-associated LIM protein, which binds to the spectrin-like repeats of alpha-actinin-2. Here, we report the identification and characterization of a new skeletal muscle protein containing a PDZ domain that binds to the COOH-terminal region of alpha-actinin-2. This novel 31-kD protein is specifically expressed in heart and skeletal muscle. Using antibodies produced to a fragment of the protein, we can show its location in the sarcomere at the level of the Z-band by immunoelectron microscopy. At least two proteins, 32 kD and 78 kD, can be detected by Western blot analysis of both heart and skeletal muscle, suggesting the existence of alternative forms of the protein. In fact, several forms were found that appear to be the result of alternative splicing. The transcript coding for this Z-band alternatively spliced PDZ motif (ZASP) protein maps on chromosome 10q22.3-10q23.2, near the locus for infantile-onset spinocerebellar ataxia.
Links (links to other resources describing this domain)
