Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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ZnF_CDGSH CDGSH-type zinc finger. Function unknown.

SMART accession number:	SM00704
Description:
Interpro abstract (IPR006622):	This entry represents iron-sulphur domain containing proteins that have a CDGSH sequence motif (although the Ser residue can also be an Ala or Thr), and is found in proteins from a wide range of organisms with the exception of fungi. The CDGSH-type domain binds a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family [(PUBMED:17376863)]. CDGSH-type domains are found in mitoNEET, an iron-containing integral protein of the outer mitochondrian membrane (OMM). MitoNEET forms a dimeric structure with a NEET fold, and contains two domains: a beta-cap region and a cluster-binding domain that coordinated two acid-labile 2Fe-2S clusters (one bound to each protomer) [(PUBMED:17766440)]. The CDGSH iron-sulphur domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, (IPR019610) [(PUBMED:17584744), (PUBMED:17766440)]. The whole protein regulates oxidative capacity and may function in electron transfer, for instance in redox reactions with metabolic intermediates, cofactors and/or proteins localized at the OMM.
GO component:	intracellular membrane-bounded organelle (GO:0043231)
GO function:	2 iron, 2 sulfur cluster binding (GO:0051537)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 437 ZnF_CDGSH domains in 265 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a ZnF_CDGSH domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with ZnF_CDGSH domain is also avaliable.

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  Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 40.00 map00251 Glutamate metabolism 40.00 map00910 Nitrogen metabolism 20.00 map00272 Cysteine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with ZnF_CDGSH domain which could be assigned to a KEGG orthologous group, and not all proteins containing ZnF_CDGSH domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of ZnF_CDGSH domains in PDB

  PDB code	Main view	Title
  2qd0		Crystal structure of mitoneet
  2qh7		Mitoneet is a uniquely folded 2fe-2s outer mitochondrial membrane protein stabilized by pioglitazone
  2r13		Crystal structure of human mitoneet reveals a novel [2fe- 2s] cluster coordination
  3ew0		The novel 2fe-2s outer mitochondrial protein mitoneet displays conformational flexibility in its n-terminal cytoplasmic tethering domain
  3fnv		Crystal structure of miner1: the redox-active 2fe-2s protein causative in wolfram syndrome 2

• Links (links to other resources describing this domain)

• INTERPRO	IPR006622

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