eIF5C

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5
eIF5C
SMART accession number:SM00515
Description: -
Interpro abstract (IPR003307):

Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukayrotic initiation factors (eIFs) are included. The W2 domain (two invariant tryptophans) is a region of ~165 amino acids which is found in the C terminus of the following eIFs [(PUBMED:8520487), (PUBMED:10958635), (PUBMED:14681227), (PUBMED:16616930), (PUBMED:16781736)]:

  • Eukaryotic translation initiation factor 2B epsilon (eIF-2B-epsilon).
  • Eukaryotic translation initiation factor 4 gamma (eIF-4-gamma).
  • Eukaryotic translation initiation factor 5 (eIF-5), a GTPase-activating protein (GAP) specific for eIF2.

The W2 domain has a globular fold and is exclusively composed out of alpha- helices [(PUBMED:14681227), (PUBMED:16616930), (PUBMED:16781736)]. The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions.

GO function:protein binding (GO:0005515)
Family alignment:
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There are 1337 eIF5C domains in 1335 proteins in SMART's nrdb database.

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