Ca2+ insensitive EF hand
SMART accession number:SM01184
Description: EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes. EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets. This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties. The calcium insensitive EF hand is still able to mediate protein-protein recognition (PUBMED:11573089).
Family alignment:
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There are 1094 efhand_Ca_insen domains in 1093 proteins in SMART's nrdb database.

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