This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation (PUBMED:11163248).
This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation [(PUBMED:11163248)].
Family alignment:
There are 217
s48_45 domains in 108 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with s48_45 domain is also avaliable.
A central role for P48/45 in malaria parasite male gamete fertility.
Cell. 2001; 104: 153-64
Display abstract
Fertilization and zygote development are obligate features of the malariaparasite life cycle and occur during parasite transmission to mosquitoes.The surface protein PFS48/45 is expressed by male and female gametes ofPlasmodium falciparum and PFS48/45 antibodies prevent zygote developmentand transmission. Here, gene disruption was used to show that Pfs48/45 andthe ortholog Pbs48/45 from a rodent malaria parasite P. berghei play aconserved and important role in fertilization. p48/45- parasites had areduced capacity to produce oocysts in mosquitoes due to greatly reducedzygote formation. Unexpectedly, only male gamete fertility of p48/45-parasites was affected, failing to penetrate otherwise fertile femalegametes. P48/45 is shown to be a surface protein of malaria parasites witha demonstrable role in fertilization.
Links (links to other resources describing this domain)
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