small_GTPaseSmall GTPase of the Ras superfamily; ill-defined subfamily
|SMART accession number:||SM00010|
|Description:||SMART predicts Ras-like small GTPases of the ARF, RAB, RAN, RAS, and SAR subfamilies. Others that could not be classified in this way are predicted to be members of the small GTPase superfamily without predictions of the subfamily.|
Click on the following links for more information.
- Evolution (species in which this domain is found)
Click on to expand nodes. To display all proteins with a small_GTPase domain in a specific node, click on it.
This tree shows only several representative species. The complete taxonomic breakdown of all proteins with small_GTPase domain is also avaliable.
- Cellular role (predicted cellular role)
Binding / catalysis: GTP hydrolysis
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Bos JL
- Ras-like GTPases.
- Biochim Biophys Acta. 1997; 1333: 1931-1931
- Geyer M, Wittinghofer A
- GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins.
- Curr Opin Struct Biol. 1997; 7: 786-92
- Display abstract
Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated.
- Sprang SR
- G proteins, effectors and GAPs: structure and mechanism.
- Curr Opin Struct Biol. 1997; 7: 849-56
- Display abstract
G proteins from a diverse family of regulatory GTPases which, in the GTP-bound state, bind to and activate downstream effectors. Structures of Ras homologs bound to effector domains have revealed mechanisms by which G proteins couple GTP binding to effector activation and achieve specificity. Complexes between structurally unrelated GTPase-activating proteins with complementary G proteins suggest common mechanisms by which GTP hydrolysis is stimulated via direct interactions with conformationally labile switch regions of the G protein.
- Metabolism (metabolic pathways involving proteins which contain this domain)
% proteins involved KEGG pathway ID Description 20.00 map04670 Leukocyte transendothelial migration 14.55 map04530 Tight junction 12.73 map04510 Focal adhesion 10.91 map04916 Melanogenesis 10.91 map04730 Long-term depression 7.27 map04540 Gap junction 7.27 map04360 Axon guidance 7.27 map04914 Progesterone-mediated oocyte maturation 5.45 map04111 Cell cycle - yeast 1.82 map05212 Pancreatic cancer 1.82 map04340 Hedgehog signaling pathway
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with small_GTPase domain which could be assigned to a KEGG orthologous group, and not all proteins containing small_GTPase domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of small_GTPase domains in PDB
PDB code Main view Title 1byu Canine gdp-ran 1e0s Small g protein arf6-gdp 1fqj Crystal structure of the heterotrimeric complex of the rgs domain of rgs9, the gamma subunit of phosphodiesterase and the gt/i1 chimera alpha subunit [(rgs9)-(pdegamma)- (gt/i1alpha)-(gdp)-(alf4-)-(mg2+)] 1fqk Crystal structure of the heterodimeric complex of the rgs domain of rgs9, and the gt/i1 chimera alpha subunit [(rgs9)-(gt/i1alpha)-(gdp)-(alf4-)-(mg2+)] 1got Heterotrimeric complex of a gt-alpha/gi-alpha chimera and the gt-beta-gamma subunits 1svk Structure of the k180p mutant of gi alpha subunit bound to alf4 and gdp 1svs Structure of the k180p mutant of gi alpha subunit bound to gppnhp. 1xzp Structure of the gtp-binding protein trme from thermotoga maritima 1xzq Structure of the gtp-binding protein trme from thermotoga maritima complexed with 5-formyl-thf 1yzg Structure of human adp-ribosylation factor-like 8 1z6y Structure of human adp-ribosylation factor-like 5 1zd9 Structure of human adp-ribosylation factor-like 10b 1zj6 Crystal structure of human arl5 2a5d Structural basis for the activation of cholera toxin by human arf6-gtp 2a5f Cholera toxin a1 subunit bound to its substrate, nad+, and its human protein activator, arf6 2a5g Cholera toxin a1 subunit bound to arf6(q67l) 2al7 Structure of human adp-ribosylation factor-like 10c 2bmj Gtpase like domain of centaurin gamma 1 (human) 2cjw Crystal structure of the small gtpase gem (gemdndcam) in complex to mg.gdp 2dpx Crystal structure of human rad gtpase 2fh5 The structure of the mammalian srp receptor 2g3y Crystal structure of the human small gtpase gem 2gjs The crystal structure of human rrad in complex with gdp 2go5 Structure of signal recognition particle receptor (sr) in complex with signal recognition particle (srp) and ribosome nascent chain complex 2h16 Structure of human adp-ribosylation factor-like 5 (arl5) 2h18 Structure of human adp-ribosylation factor-like 10b (arl10b) 2h57 Crystal structure of human adp-ribosylation factor-like 6 2ht6 Crystal structure of human gem g-domain bound to gdp 2hxs Crystal structure of rab28a gtpase in the inactive (gdp-3'p- bound) form 2iwr Gtpase like domain of centaurin gamma 1 (human) 2j5x Structure of the small g protein arf6 in complex with gtpgammas 2nzj The crystal structure of rem1 in complex with gdp 2zej Structure of the roc domain from the parkinson's disease- associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 3c5c Crystal structure of human ras-like, family 12 protein in complex with gdp 3cbq Crystal structure of the human rem2 gtpase with bound gdp 3d6t Structure of the roc domain from the parkinson's disease- associated leucine-rich repeat kinase 2 reveals a dimeric gtpase 3dpu Roccor domain tandem of rab family protein (roco) 3e5h Crystal structure of rab28 gtpase in the active (gppnhp- bound) form 3gee Crystal structure of mnme from chlorobium tepidum in complex with gdp and folinic acid 3geh Crystal structure of mnme from nostoc in complex with gdp, folinic acid and zn 3gei Crystal structure of mnme from chlorobium tepidum in complex with gcp 3gj0 Crystal structure of human rangdp 3gj3 Crystal structure of human rangdp-nup153znf2 complex 3gj4 Crystal structure of human rangdp-nup153znf3 complex 3gj5 Crystal structure of human rangdp-nup153znf4 complex 3gj6 Crystal structure of human rangdp-nup153znf1 complex 3gj7 Crystal structure of human rangdp-nup153znf12 complex 3gj8 Crystal structure of human rangdp-nup153znf34 complex 3ihw Crystal structure of the ras-like domain of centg3