tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
SMART accession number:SM00552
Description: -
Interpro abstract (IPR002466):

Editase ( EC 3.5 ) are enzymes that alter mRNA by catalyzing the site-selective deamination of adenosine residue into inosine residue. The editase domain contains the active site and binds three Zn atoms [ (PUBMED:9159072) ].

Several editases share a common global arrangement of domains, from N to C terminus: two 'double-stranded RNA-specific adenosine deaminase' (DRADA) repeat domains ( IPR000607 ), followed by three 'double-stranded RNA binding' (DsRBD) domains, followed by the editase domain. Other editases have a simplified domains structure with no DRADA_REP and possibly fewer DSRBD domains. Editase that deaminate cytidine are not detected by this signature.

GO process:RNA processing (GO:0006396)
GO function:RNA binding (GO:0003723), adenosine deaminase activity (GO:0004000)
Family alignment:
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There are 1742 ADEAMc domains in 1742 proteins in SMART's nrdb database.

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