AIR carboxylase
SMART accession number:SM01001
Description: Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.
Interpro abstract (IPR000031):

The novo purine biosynthesis proceeds by two divergent paths. In bacteria, yeasts, and plants, 5-aminoimidazole ribonucleotide (AIR) is converted to 4-carboxy-AIR (CAIR) by two enzymes: N5-carboxy-AIR (N5-CAIR) synthetase (PurK) and N5-CAIR mutase (class I PurE). In animals, the conversion of AIR to CAIR requires a single enzyme, AIR carboxylase (class II PurE) [ (PUBMED:7918411) ]. Class I and class II PurEs are mechanistically related but bind different substrates. In yeast and plants PurE is found in PurK-class I PurE fusion proteins, known as ADE2 [ (PUBMED:8111040) (PUBMED:9500840) ], while animal class II PurEs are found in PurC-PurE fusion proteins, also known as ADE2 or PAICS [ (PUBMED:7918410) ].

GO process:'de novo' IMP biosynthetic process (GO:0006189)
Family alignment:
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There are 23473 AIRC domains in 23424 proteins in SMART's nrdb database.

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