S-adenosyl-L-homocysteine hydrolase, NAD binding domain
SMART accession number:SM00997
Description: -
Interpro abstract (IPR015878):

S-adenosyl-L-homocysteine hydrolase ( EC ) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD + as a cofactor. AdoHcyase is a highly conserved protein [ (PUBMED:1631127) ] of about 430 to 470 amino acids.

This entry represents the glycine-rich region in the central part of AdoHcyase, which is thought to be involved in NAD-binding [ (PUBMED:1631127) ].

Family alignment:
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There are 17321 AdoHcyase_NAD domains in 17318 proteins in SMART's nrdb database.

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