Aerolysin toxin
SMART accession number:SM00999
Description: This family represents the pore forming lobe of aerolysin.
Interpro abstract (IPR005830):

Aerolysin [ (PUBMED:3584074) ] is a cytolytic toxin exported by Aeromonas hydrophila, a Gram-negative bacterium associated with diarrhoeal diseases and deep wound infections [ (PUBMED:7510043) ]. The mature toxin binds to eukaryotic cells and aggregates to form holes (approximately 3 nm in diameter) leading to the destruction of the membrane permeability barrier and osmotic lysis. The structure of proaerolysin has been determined to 2.8A resolution and shows the protoxin to adopt a novel fold [ (PUBMED:7510043) ]. Images of an aerolysin oligomer derived from electron microscopy have helped to construct a model of the protein and to outline a mechanism by which it might insert into lipid bilayers to form ion channels [ (PUBMED:7510043) ].

GO process:pathogenesis (GO:0009405)
GO component:extracellular region (GO:0005576)
Family alignment:
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There are 81 Aerolysin domains in 81 proteins in SMART's nrdb database.

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