Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

B2-adapt-app_C Beta2-adaptin appendage, C-terminal sub-domain

SMART accession number:	SM01020
Description:	Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).
Interpro abstract (IPR015151):	This entry represents a subdomain of the appendage (ear) domain of beta-adaptin. This domain has a three-layer arrangement, alpha-beta-alpha, with a bifurcated antiparallel beta-sheet [ (PUBMED:10430869) ]. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [ (PUBMED:10944104) ].
GO process:	intracellular protein transport (GO:0006886), vesicle-mediated transport (GO:0016192)
GO component:	clathrin adaptor complex (GO:0030131)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1780 B2-adapt-app_C domains in 1780 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing B2-adapt-app_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with B2-adapt-app_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing B2-adapt-app_C domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Structure (3D structures containing this domain)

• 3D Structures of B2-adapt-app_C domains in PDB

  PDB code	Main view	Title
  1e42		Beta2-adaptin appendage domain, from clathrin adaptor AP2
  2g30		beta appendage of AP2 complexed with ARH peptide
  2iv8		beta appendage in complex with b-arrestin peptide
  2iv9		B2-appendage from AP2 in complex with Eps15 peptide
  2mj7		Solution NMR structure of beta-adaptin appendage domain of human adaptor protein complex 4 subunit beta, Northeast Structural Genomics Consortium (NESG) Target HR8998C
  3h1z		Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2
  3hs9		Intersectin 1-peptide-AP2 beta ear complex

• Links (links to other resources describing this domain)

• PFAM	B2-adapt-app_C
  INTERPRO	IPR015151

Send comments to Ivica Letunic