Sensors of blue-light using FAD
SMART accession number:SM01034
Description: The BLUF domain has been shown to bind FAD in the AppA protein (Q53119). AppA is involved in the repression of photosynthesis genes in response to blue-light.
Interpro abstract (IPR007024):

The BLUF domain (named for sensors of Blue-Light Using FAD) is an FAD-binding protein domain. BLUF domains are present in various proteins, primarily from bacteria. For example a BLUF domain is found at the N terminus of the AppA protein from Rhodobacter sphaeroides [ (PUBMED:16323221) ]. BLUF domains are involved in sensing blue-light (and possibly redox) using FAD, and are similar to the flavin-binding PAS domains and cryptochromes. Their predicted secondary structure reveals that the BLUF domains have a novel FAD-binding fold [ (PUBMED:12368079) ].

GO function:blue light photoreceptor activity (GO:0009882), FAD binding (GO:0071949)
Family alignment:
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There are 5570 BLUF domains in 5547 proteins in SMART's nrdb database.

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