Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Beta-Casp Beta-Casp domain

SMART accession number:	SM01027
Description:	The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains.
Interpro abstract (IPR022712):	The beta-CASP domain is found C-terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains [ (PUBMED:17128255) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 15486 Beta-Casp domains in 15481 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Beta-Casp domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Beta-Casp domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Beta-Casp domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: transcription
  

• Structure (3D structures containing this domain)

• 3D Structures of Beta-Casp domains in PDB

  PDB code	Main view	Title
  2dkf		Crystal Structure of TTHA0252 from Thermus thermophilus HB8, a RNA Degradation Protein of the Metallo-beta-lactamase Superfamily
  2i7t		Structure of human CPSF-73
  2i7v		Structure of Human CPSF-73
  2i7x		Structure of Yeast CPSF-100 (Ydh1p)
  2xr1		DIMERIC ARCHAEAL CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR WITH N-TERMINAL KH DOMAINS (KH-CPSF) FROM METHANOSARCINA MAZEI
  2ycb		Structure of the archaeal beta-CASP protein with N-terminal KH domains from Methanothermobacter thermautotrophicus
  3a4y		Crystal Structure of H61A mutant TTHA0252 from Thermus thermophilus HB8
  3af5		The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii
  3af6		The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii complexed with RNA-analog
  3idz		Crystal Structure of S378Q mutant TTHA0252 from Thermus thermophilus HB8
  3ie0		Crystal Structure of S378Y mutant TTHA0252 from Thermus thermophilus HB8
  3ie1		Crystal structure of H380A mutant TTHA0252 from Thermus thermophilus HB8 complexed with RNA
  3ie2		Crystal Structure of H400V mutant TTHA0252 from Thermus thermophilus HB8
  3iek		Crystal Structure of native TTHA0252 from Thermus thermophilus HB8
  3iel		Crystal Structure of TTHA0252 from Thermus thermophilus HB8 complexed with UMP
  3iem		Crystal Structure of TTHA0252 from Thermus thermophilus HB8 complexed with RNA analog

• Links (links to other resources describing this domain)

• INTERPRO	IPR022712
  PFAM	Beta-Casp

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