Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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CBD_IV Cellulose Binding Domain Type IV

SMART accession number:	SM00606
Description:	-
Interpro abstract (IPR006584):	This entry represents a type IV cellulose binding domain. It is a sub-domain of the carbohydrate-binding module, family 6 . Regarding the function, it shows endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans [ (PUBMED:1938968) ].
GO function:	carbohydrate binding (GO:0030246)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 7822 CBD_IV domains in 6191 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing CBD_IV domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CBD_IV domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing CBD_IV domain in the selected taxonomic class.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 27.27 map00940 Phenylpropanoid biosynthesis 27.27 map00500 Starch and sucrose metabolism 27.27 map00460 Cyanoamino acid metabolism 9.09 map00562 Inositol phosphate metabolism 9.09 map00632 Benzoate degradation via CoA ligation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with CBD_IV domain which could be assigned to a KEGG orthologous group, and not all proteins containing CBD_IV domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of CBD_IV domains in PDB

  PDB code	Main view	Title
  1gmm		Carbohydrate binding module CBM6 from xylanase U Clostridium thermocellum
  1nae		Structure of CsCBM6-3 from Clostridium stercorarium in complex with xylotriose
  1o8p		Unbound structure of CsCBM6-3 from Clostridium stercorarium
  1o8s		Structure of CsCBM6-3 from Clostridium stercorarium in complex with cellobiose
  1od3		Structure of CBM6-3 in complex with laminaribiose
  1uxx		CBM6ct from Clostridium thermocellum in complex with xylopentaose
  1uxz		Carbohydrate binding module (CBM6cm-2) from Cellvibrio mixtus lichenase 5A
  1uy0		Carbohydrate binding module (CBM6cm-2) from Cellvibrio mixtus lichenase 5A in complex with glc-1,3-glc-1,4-glc-1,3-glc
  1uy1		Binding sub-site dissection of a family 6 carbohydrate-binding module by X-ray crystallography and isothermal titration calorimetry
  1uy2		Binding sub-site dissection of a family 6 carbohydrate-binding module by X-ray crystallography and isothermal titration calorimetry
  1uy3		Binding sub-site dissection of a family 6 carbohydrate-binding module by X-ray crystallography and isothermal titration calorimetry
  1uy4		Binding sub-site dissection of a family 6 carbohydrate-binding module by X-ray crystallography and isothermal titration calorimetry
  1uyx		Carbohydrate binding module (CBM6cm-2) from Cellvibrio mixtus lichenase 5A in complex with cellobiose
  1uyy		Carbohydrate binding module (CBM6cm-2) from Cellvibrio mixtus lichenase 5A in complex with cellotriose
  1uyz		Carbohydrate binding module (CBM6cm-2) from Cellvibrio mixtus lichenase 5A in complex with xylotetraose
  1uz0		Carbohydrate binding module (CBM6cm-2) from Cellvibrio mixtus lichenase 5A in complex with Glc-4Glc-3Glc-4Glc
  1w9s		Structure of a beta-1,3-glucan binding CBM6 from Bacillus halodurans
  1w9t		Structure of a beta-1,3-glucan binding CBM6 from Bacillus halodurans in complex with xylobiose
  1w9w		Structure of a beta-1,3-glucan binding CBM6 from Bacillus halodurans in complex with laminarihexaose
  2cdo		structure of agarase carbohydrate binding module in complex with neoagarohexaose
  2cdp		Structure of a CBM6 in complex with neoagarohexaose
  2v4v		Crystal Structure of a Family 6 Carbohydrate-Binding Module from Clostridium cellulolyticum in complex with xylose
  2y8k		Structure of CtGH5-CBM6, an arabinoxylan-specific xylanase.
  3c7e		Crystal structure of a glycoside hydrolase family 43 arabinoxylan arabinofuranohydrolase from Bacillus subtilis.
  3c7f		Crystal structure of a glycoside hydrolase family 43 arabinoxylan arabinofuranohydrolase from bacillus subtilis in complex with xylotriose.
  3c7g		Crystal structure of a glycoside hydrolase family 43 arabinoxylan arabinofuranohydrolase from Bacillus subtilis in complex with xylotetraose.
  3c7h		Crystal structure of glycoside hydrolase family 43 arabinoxylan arabinofuranohydrolase from Bacillus subtilis in complex with AXOS-4-0.5.
  3c7o		Crystal structure of a glycoside hydrolase family 43 arabinoxylan arabinofuranohydrolase from Bacillus subtilis in complex with cellotetraose.
  5fui		5FUI
  5g56		5G56
  5la0		5LA0
  5la1		5LA1
  5la2		5LA2

• Links (links to other resources describing this domain)

• INTERPRO	IPR006584

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