The CFEM domain is a fungal-specific domain that contains eight cysteines and is found in some proteins with proposed roles in fungal pathogenesis [ (PUBMED:12633989) ].
The structure of the CFEM domain containing protein 'Surface antigen protein 2' from Candida albicans ( Q5A0X8 ) has been solved [ (PUBMED:27617569) ].
Family alignment:
There are 275 CFEM domains in 82 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing CFEM domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CFEM domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing CFEM domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
An eight-cysteine-containing CFEM domain unique to a group of fungal membrane proteins.
Trends Biochem Sci. 2003; 28: 118-21
Display abstract
CFEM, an eight cysteine-containing domain, has been identified by analyzing over 25 fungal sequences selected from database sequence searches. Features of CFEM suggest that it is a novel domain with characteristics distinct from known cysteine-rich domains. Some CFEM-containing proteins (e.g. Pth11 from Magnaporthe grisea) are proposed to have important roles in fungal pathogenesis.
An eight-cysteine-containing CFEM domain unique to a group of fungalmembrane proteins.
Trends Biochem Sci. 2003; 28: 118-21
Display abstract
CFEM, an eight cysteine-containing domain, has been identified byanalyzing over 25 fungal sequences selected from database sequencesearches. Features of CFEM suggest that it is a novel domain withcharacteristics distinct from known cysteine-rich domains. SomeCFEM-containing proteins (e.g. Pth11 from Magnaporthe grisea) are proposedto have important roles in fungal pathogenesis.