SMART accession number:SM00880
Description: The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family . It has conserved histidines that may chelate metals.
Interpro abstract (IPR007899):

The CHAD (conserved histidine alpha-helical domain) is an uncharacterised domain, with a characteristic pattern of conserved histidines and other charged residues. It is predicted to adopt an alpha-helical fold. The sequence conservation pattern suggests that this domain is likely to contain two repeat units, with at least 4 helices each, at its core. The conserved charged residues could form a strongly polar surface that could participate, either in metal chelation, or act as phosphoacceptors [ (PUBMED:12456267) ].

Some proteins known to contain a CHAD domain are listed below:

  • Escherichia coli uncharacterised protein YgiF.
  • Mycobacterium tuberculosis uncharacterised protein Rv2226/MT2285.
Family alignment:
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There are 9559 CHAD domains in 9557 proteins in SMART's nrdb database.

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