Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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CKS Cyclin-dependent kinase regulatory subunit

SMART accession number:	SM01084
Description:	Cyclin-dependent kinase regulatory subunit.
Interpro abstract (IPR000789):	In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [ (PUBMED:3322810) ]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [ (PUBMED:8211159) ]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [ (PUBMED:8491379) ]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [ (PUBMED:8491379) (PUBMED:8211159) ].
GO function:	cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1999 CKS domains in 1996 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing CKS domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with CKS domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing CKS domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Structure (3D structures containing this domain)

• 3D Structures of CKS domains in PDB

  PDB code	Main view	Title
  1buh		CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1
  1cks		HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL
  1dks		CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE
  1dkt		CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 COMPLEX WITH METAVANADATE
  1puc		P13SUC1 IN A STRAND-EXCHANGED DIMER
  1qb3		CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN CKS1
  1sce		CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN SUC1 REVEALS A NOVEL BETA-HINGE CONFORMATIONAL SWITCH
  2ass		Crystal structure of the Skp1-Skp2-Cks1 complex
  2ast		Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
  3qy2		Crystal structure of the P93A monomer mutant of S. cerevisiae Cks1
  4lpa		Crystal structure of a Cdc6 phosphopeptide in complex with Cks1
  4y72		4Y72
  4yc3		4YC3
  4yc6		4YC6
  5hq0		5HQ0

• Links (links to other resources describing this domain)

• INTERPRO	IPR000789
  PFAM	CKS

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