Cyclin-dependent kinase regulatory subunit
SMART accession number:SM01084
Description: Cyclin-dependent kinase regulatory subunit.
Interpro abstract (IPR000789):

In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [ (PUBMED:3322810) ]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [ (PUBMED:8211159) ]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [ (PUBMED:8491379) ]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [ (PUBMED:8491379) (PUBMED:8211159) ].

GO function:cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)
Family alignment:
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There are 1999 CKS domains in 1996 proteins in SMART's nrdb database.

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