Casein kinase II regulatory subunit
SMART accession number:SM01085
Description: -
Interpro abstract (IPR000704):

Casein kinase, a ubiquitous well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Ser or Thr in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits [ (PUBMED:2666134) (PUBMED:1856204) ]. However, some species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta') [ (PUBMED:7737972) ].

The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif [ (PUBMED:7737972) ]. The beta subunit contains, in its central section, a cysteine-rich motif, CX(n)C, that could be involved in binding a metal such as zinc [ (PUBMED:8027080) ]. The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase [ (PUBMED:7737972) ].

GO component:protein kinase CK2 complex (GO:0005956)
GO function:protein kinase regulator activity (GO:0019887)
Family alignment:
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There are 3104 CK_II_beta domains in 3099 proteins in SMART's nrdb database.

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