SMART accession number:SM01111
Description: In molecular biology, the CVNH domain (CyanoVirin-N Homology domain) is a conserved protein domain. It is found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as proteins from filamentous ascomycetes and in the fern Ceratopteris richardii.(PMID 16003744)
Interpro abstract (IPR011058):

Cyanovirin-N (CV-N) is an 11kDa protein from the cyanobacterium Nostoc ellipsosporum that displays virucidal activity against several viruses, including human immunodeficiency virus (AIDS). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope [ (PUBMED:12678493) ]. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin [ (PUBMED:12878514) ].

The CV-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes [ (PUBMED:16003744) ]. CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta-sheet and beta-hairpins [ (PUBMED:12110688) ].

Family alignment:
View or

There are 347 CVNH domains in 331 proteins in SMART's nrdb database.

Click on the following links for more information.