Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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Cyclin_C

SMART accession number:	SM01332
Description:	Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.
Interpro abstract (IPR004367):	Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [ (PUBMED:12910258) ], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E. Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2 (Herpesvirus saimiri) and Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [ (PUBMED:11056549) ]. This is the C-terminal domain of cyclins.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 14939 Cyclin_C domains in 14900 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing Cyclin_C domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Cyclin_C domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing Cyclin_C domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Galderisi U, Jori FP, Giordano A
  • Cell cycle regulation and neural differentiation.
  • Oncogene. 2003; 22: 5208-19
  • Display abstract

  • The general mechanisms that control the cell cycle in mammalian cells have beenstudied in depth and several proteins that are involved in the tight regulationof cell cycle progression have been identified. However, the analysis of whichmolecules participate in cell cycle exit of specific cell lineages is notexhaustive yet. Moreover, the strict relation between cell cycle exit andinduction of differentiation has not been fully understood and seems to depend onthe cell type. Several in vivo and in vitro studies have been performed in thelast few years to address these issues in cells of the nervous system. In thisreview, we focus our attention on cyclin-cyclin-dependent kinase complexes,cyclin kinase inhibitors, genes of the retinoblastoma family, p53 and N-Myc, and we aim to summarize the latest evidence indicating their involvement in thecontrol of the cell cycle and induction of differentiation in different celltypes of the peripheral and central nervous systems. Studies on nervous systemtumors and a possible contributory role in tumorigenesis of polyomavirus Tantigen are reported to point out the critical contribution of some cell cycleregulators to normal neural and glial development.

• Structure (3D structures containing this domain)

• 3D Structures of Cyclin_C domains in PDB

  PDB code	Main view	Title
  1e9h		Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound
  1fin		CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
  1fvv		THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
  1gy3		pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate
  1h1p		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058
  1h1q		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094
  1h1r		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086
  1h1s		Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102
  1h24		CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
  1h25		CDK2/CyclinA in complex with an 11-residue recruitment peptide from E2F
  1h26		CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
  1h27		CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27
  1h28		CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
  1jst		PHOSPHORYLATED CYCLIN-DEPENDENT KINASE-2 BOUND TO CYCLIN A
  1jsu		P27(KIP1)/CYCLIN A/CDK2 COMPLEX
  1ogu		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR
  1oi9		Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
  1oiu		Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
  1oiy		Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
  1okv		Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2
  1okw		Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(m-Cl-Phe)-NH2
  1ol1		Cyclin A binding groove inhibitor H-Cit-Cit-Leu-Ile-(p-F-Phe)-NH2
  1ol2		Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Asn-(p-F-Phe)-NH2
  1p5e		The strucure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)
  1pkd		THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
  1qmz		PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX
  1urc		Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly
  1vin		BOVINE CYCLIN A3
  1vyw		Structure of CDK2/Cyclin A with PNU-292137
  1w98		The structural basis of CDK2 activation by cyclin E
  2b9r		Crystal Structure of Human Cyclin B1
  2bkz		STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611
  2bpm		STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529
  2c4g		STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
  2c5n		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
  2c5o		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
  2c5v		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
  2c5x		Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
  2c6t		Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor
  2cch		The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
  2cci		Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
  2cjm		Mechanism of CDK inhibition by active site phosphorylation: CDK2 Y15p T160p in complex with cyclin A structure
  2g9x		Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
  2i40		Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor
  2iw6		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
  2iw8		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
  2iw9		STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
  2jgz		Crystal structure of phospho-CDK2 in complex with Cyclin B
  2uue		REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
  2uzb		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
  2uzd		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
  2uze		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
  2uzl		Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
  2v22		REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
  2w96		Crystal Structure of CDK4 in complex with a D-type cyclin
  2w99		Crystal Structure of CDK4 in complex with a D-type cyclin
  2w9f		Crystal Structure of CDK4 in complex with a D-type cyclin
  2w9z		Crystal Structure of CDK4 in complex with a D-type cyclin
  2wev		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
  2wfy		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
  2whb		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
  2wih		STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125
  2wip		STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID
  2wma		Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
  2wmb		Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
  2wpa		Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing
  2wxv		Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor
  2x1n		Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design
  3bht		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3
  3bhu		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
  3bhv		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B
  3ddp		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
  3ddq		Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
  3dog		Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1
  3eid		CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
  3ej1		CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
  3eoc		Cdk2/CyclinA complexed with a imidazo triazin-2-amine
  3f5x		CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site
  3g33		Crystal structure of CDK4/cyclin D3
  3my5		CDk2/cyclinA in complex with DRB
  3qhr		Structure of a pCDK2/CyclinA transition-state mimic
  3qhw		Structure of a pCDK2/CyclinA transition-state mimic
  3tnw		Structure of CDK2/cyclin A in complex with CAN508
  4bck		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
  4bcm		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
  4bcn		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
  4bco		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
  4bcp		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
  4bcq		Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
  4cfm		4CFM
  4cfn		Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
  4cfu		4CFU
  4cfv		4CFV
  4cfw		Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
  4cfx		4CFX
  4eoi		Thr 160 phosphorylated CDK2 K89D, Q131E - human cyclin A3 complex with the inhibitor RO3306
  4eoj		Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with ATP
  4eok		Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
  4eol		Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor RO3306
  4eom		Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with ATP
  4eon		Thr 160 phosphorylated CDK2 H84S, Q85M, Q131E - human cyclin A3 complex with the inhibitor RO3306
  4eoo		Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with ATP
  4eop		Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306
  4eoq		Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with ATP
  4eor		Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102
  4eos		Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor RO3306
  4fx3		Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
  4i3z		Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions
  4ii5		Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION
  4y72		4Y72
  4yc3		4YC3
  5cyi		5CYI
  5hq0		5HQ0
  5if1		5IF1
  5l2w		5L2W

• Links (links to other resources describing this domain)

• PFAM	Cyclin_C
  INTERPRO	IPR004367

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