Doublesex DNA-binding motif
SMART accession number:SM00301
Description: -
Interpro abstract (IPR001275):

DMRT genes encode a conserved family of transcription factors that share a unique DNA binding motif, the DM domain [ (PUBMED:28774758) ]. This domain was first discovered in the doublesex proteins of Drosophila melanogaster [ (PUBMED:9490411) ]. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides [ (PUBMED:8978051) ]. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription [ (PUBMED:1907913) (PUBMED:3046751) ]. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences [ (PUBMED:8978051) (PUBMED:9927589) (PUBMED:10898790) ]. The NMR analysis of the DSX DM domain [ (PUBMED:10898790) ] revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.

GO process:regulation of transcription, DNA-templated (GO:0006355)
GO function:sequence-specific DNA binding (GO:0043565)
Family alignment:
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There are 3225 DM domains in 3008 proteins in SMART's nrdb database.

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