Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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DUF1785

SMART accession number:	SM01163
Description:	This region is found in argonaute [(PUBMED:16216572)] proteins and often co-occurs with BAG (SM00264) and Piwi (SM00950).
Interpro abstract (IPR014811):	ArgoL1 is a region found in argonaute [ (PUBMED:16216572) ] proteins. It normally co-occurs with BAG domain ( IPR003103 ) and Piwi domain ( IPR003165 ). It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold [ (PUBMED:16061186) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 6460 DUF1785 domains in 6418 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing DUF1785 domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DUF1785 domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing DUF1785 domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Hall TM
  • Structure and function of argonaute proteins.
  • Structure. 2005; 13: 1403-8
  • Display abstract

  • Argonaute (Ago) family proteins are multidomain proteins expressed in prokaryoticand eukaryotic organisms. In eukaryotes, Ago proteins are most well known fortheir roles in RNA silencing. In prokaryotes, the functions of Ago proteins areunknown, but based on their similarity to eukaryotic Ago proteins, they could be involved in nucleic acid-directed regulatory pathways related to RNA silencing.Recent structural and biochemical studies have shed new light on the function of this family of proteins. These studies reveal how these proteins recognize andcleave RNA and suggest a function for prokaryotic family members.

• Structure (3D structures containing this domain)

• 3D Structures of DUF1785 domains in PDB

  PDB code	Main view	Title
  4f3t		Human Argonaute-2 - miR-20a complex
  4kre		Structure of Human Argonaute-1 bound to endogenous Sf9 RNA
  4krf		Structure of Human Argonaute-1 let-7 complex
  4kxt		Structure of human ARGONAUTE1 in complex with guide RNA
  4ola		Crystal Structure of Human Argonaute2
  4olb		Crystal Structure of Human Argonaute2 Bound to Tryptophan
  4w5n		4W5N
  4w5o		4W5O
  4w5q		4W5Q
  4w5r		4W5R
  4w5t		4W5T
  4z4c		4Z4C
  4z4d		4Z4D
  4z4e		4Z4E
  4z4f		4Z4F
  4z4g		4Z4G
  4z4h		4Z4H
  4z4i		4Z4I
  5js1		5JS1
  5js2		5JS2
  5ki6		5KI6

• Links (links to other resources describing this domain)

• INTERPRO	IPR014811
  PFAM	DUF1785

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