Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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DUF4205

SMART accession number:	SM01174
Description:	The proteins in this family are uncharacterized but often named FAM188B.
Interpro abstract (IPR025257):	This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4. Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to regulate the functional outcome of ubiquitylation. This entry includes MINDY-3/4. They belong to the MINDY (motif interacting with Ub-containing novel DUB) family (peptidase family C121), whose members are deubiquitinating enzymes releasing Lys48-linked ubiquitin [ (PUBMED:27292798) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 1902 DUF4205 domains in 1902 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing DUF4205 domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DUF4205 domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing DUF4205 domain in the selected taxonomic class.

• Links (links to other resources describing this domain)

• INTERPRO	IPR025257
  PFAM	DUF4205

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