The function of this domain is not known. Proteins containing this domain includes the animal FAM214 proteins and the fission yeast SPAC3H8.04 protein. From a high-throughput knockout screen, SPAC3H8.04 was identified as a protein required for meiotic chromosome segregation [ (PUBMED:16169489) ].
Family alignment:
There are 1631 DUF4210 domains in 1630 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing DUF4210 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DUF4210 domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing DUF4210 domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Novel genes required for meiotic chromosome segregation are identified by ahigh-throughput knockout screen in fission yeast.
Curr Biol. 2005; 15: 1663-9
Display abstract
Two rounds of chromosome segregation after only a single round of DNA replicationenable the production of haploid gametes from diploid precursors during meiosis. To identify genes involved in meiotic chromosome segregation, we developed anefficient strategy to knock out genes in the fission yeast on a large scale. Weused this technique to delete 180 functionally uncharacterized genes whoseexpression is upregulated during meiosis. Deletion of two genes, sgo1 and mde2,caused massive chromosome missegregation. sgo1 is required for retention ofcentromeric sister-chromatid cohesion after anaphase I. We show here that mde2 isrequired for formation of the double-strand breaks necessary for meioticrecombination.
Links (links to other resources describing this domain)
