Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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ECSIT_Cterm C-terminal domain of the ECSIT protein

SMART accession number:	SM01284
Description:	This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain.
Interpro abstract (IPR029342):	This entry represents the C-terminal domain of the evolutionarily conserved signalling intermediate in Toll pathway (ECSIT) protein, an adapter protein of the Toll/IL-1 receptor signalling pathway, which is involved in the activation of NF-kappa-B via MAP3K1 [ (PUBMED:10465784) ]. This domain is missing in isoform 2. This domain may be distantly homologous to the pleckstrin homology domain.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 546 ECSIT_Cterm domains in 544 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing ECSIT_Cterm domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with ECSIT_Cterm domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing ECSIT_Cterm domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Links (links to other resources describing this domain)

• PFAM	ECIST_Cterm
  INTERPRO	IPR029342

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